妇产科学博士专业
Doctoral Program in Obstetrics and Gynecology
导师介绍 Supervisor Profile
李志凌 Zhiling Li
邮箱及联系电话：stlizhiling@126.com, 86-15602777166
Email & Contact Number：stlizhiling@126.com, 86-15602777166
研究方向：生殖医学
Research Field：Reproductive Medicine
导师简介 Biography：
李志凌教授，医学博士，博士生导师、博士后合作导师
广东省妇产科学重点学科带头人，辅助生殖技术项目总负责人；
粤东妇产科规培基地主任，汕头大学医学院第一附属医院妇产科主任、妇产科教 研室主任
广东省医师协会生殖医学医师分会副主委、广东省临医会生殖医学专委会副主委， 广东省数个专委会常委等；汕头市医学会妇产科学分会主任委员。
研究方向：卵胚胎基础与临床研究，主持国家基金课题多项；
培养博士生/硕士生多名，在读博士获专业演讲比赛一等奖、二等奖数人次； 在站 博士后获得国家青年基金 2 项，博士后基金 2 项。
专业特长：个体化辅助生殖技术临床实施与实验室策略分析；主持诞生了多项粤 东地区多项“首例辅助生殖技术受孕婴儿”。
公益项目：围绝经期综合管理暨高龄妇女生育指导、粤东女性生育力保存。 Prof. Zhiling Li, M.D., Ph.D. Supervisor, Postdoctoral Collaborator.
Leader of the key discipline of obstetrics and gynecology in Guangdong Province and general manager of the assisted reproductive technology project.
Director of Obstetrics and Gynecology Training Base in Eastern region of Guangdong. Director of the Department of Obstetrics and Gynecology and Director of the Department of Obstetrics and Gynecology Teaching and Research, The First Affiliated Hospital of Shantou University School of Medicine.
Vice Chairman of the Reproductive Medicine Physician Branch of Guangdong Medical Association, and Vice Chairman of the Special Committee on Reproductive Medicine of the Guangdong Provincial Clinical Medical Association, standing committees of several select committees, etc., Chairman of Shantou Medical Association Obstetrics and Gynecology Branch.
Research interests: Basic and clinical studies of egg and embryos, presided over several national foundation projects. She has trained many doctoral and master's students. Several first and second prizes in professional speech contests for current Ph. Postdoctoral fellows have received two national youth grants and two postdoctoral grants.
Specialties: Clinical implementation of individualized assisted reproductive technology and analysis of laboratory strategy. She was responsible for the birth of several "first babies conceived with assisted reproductive technology" in eastern Guangdong.
Public welfare projects: comprehensive perimenopausal management and fertility guidance for senior women, and fertility preservation for women in eastern Guangdong.
已发表文章 [All are the first authors, or the corresponding authors]:
[1]. Huang J, Ru G, Sun J, et al. Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice[J]. Mol Med. 2022, 28(1):17.
[2]. Huang J, Li J, Xiao W, Li Z. Attitudes toward posthumous assisted reproduction in China: A multi-dimensional survey. Reprod Health. 2022, 19(1):122.
[3]. Huang Y, Li Z, Lin E, et al. Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos[J]. Exp Mol Med. 2021,53(11):1792-1806.
[4]. Wu Q, Zhuang T, Li Z. Dexamethasone Restores the Repressive Effect of Tumor Necrosis Factor-α on Follicular Growth and E2 Secretion During the In Vitro Culture of Preantral Follicles[J]. Reprod Sci. 2021(11):3248-3257.
[5]. Lin E, Li Z, Huang Y, et al. High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy[J]. Frontiers in Cell and Developmental Biology. 2021, 8:609290.
[6]. He P, Li Z, Xu F, et al. AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes[J]. Frontiers in Cell and Developmental Biology. 2020, 8:539485.
[7]. Chen M, Liu W, Li Z, et al. Effect of epigallocatechin-3-gallate (EGCG) on embryos inseminated with oxidative stress-induced DNA damage sperm[J]. Systems Biology in Reproductive Medicine. 2020, 66(4):244-254.
[8]. Ding Y, He P, Li Z. MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression[J]. Molecular and Cellular Biochemistry. 2020, 465(1-2):187-197.
[9]. Huang J, Ding Y, Li Z. The regulation of the follicular synchronization and sensitivity of rats with PCOS by AMH during prolonged pituitary downregulation[J]. Gene. 2019, 721:144106.
[10]. LiJ, HaS, LiZ, et al. Aurora B prevents aneuploidy via MAD2 during the first mitotic cleavage in oxidatively damaged embryos[J]. Cell Proliferation. 2019, 52(5):e12657.
[11]. Liang H, Zhang S, Li Z. Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a[J]. Drug Des Devel Ther. 2019, 24(13): 2057-2066.
[12]. Huang Y, Ha S, Li Z, et al. CHK1-CENP B/MAD2 is associated with mild oxidative damage- induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization. Free Radic Biol Med. 2019, 137:181-193.
[13]. Wu Q, Li Z, Huang Y, et al. Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint. Oxid Med Cell Longev. 2017, 2017:2103190.
[14]. QianD, LiZ, Zhang Y, et al. Response of Mouse Zygotes Treated with Mild Hydrogen Peroxide as a Model to Reveal Novel Mechanisms of Oxidative Stress-Induced Injury in Early Embryos. Oxid Med Cell Longev. 2016, 2016:1521428.
[15]. Zhang Y, Qian D, Li Z, et al. Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2. Cell Stress Chaperones. 2016, 21(4):687-696.
[16]. Huang J, Wang X, Li Z, et al. Effects of GnRH agonists on the expression of developmental follicular anti-mullerian hormone in varying follicular stages in cyclic mice in vivo. Mol Med Rep. 2015, 12(3):4305-4313.
[17]. Song Y, Li Z, Wang B, et al. Phospho-Cdc25 correlates with activating G2/M checkpoint in mouse zygotes fertilized with hydrogen peroxide-treated mouse sperm. Mol Cell Biochem. 2014, 396(1-2):41-48.
[18]. Song Y, Li Z, Wu X, et al. Effectiveness of the antagonist/letrozole protocol for treating poor responders undergoing in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Gynecol Endocrinol. 2014, 30(5):330-334.
[19]. Wang B, LiZ, Wang C, et al. Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymalmouse sperm. PLoS One. 2013, 10;8(9):e73987.
[20]. Xiao J, Liu Y, Li Z, et al. Effects of the insemination of hydrogen peroxide-treated epididymal mouse spermatozoa on γH2AX repair and embryo development. PLoS One. 2012, 7(6):e38742.
[21]. Li Z, Zhou Y, Liu R, et al. Effects of semen processing on the generation of reactive oxygen species and mitochondrial membrane potential of human spermatozoa. Andrologia. 2012, 44(3):157-163.
[22]. Li Z, Lin Q, Liu R, et al. Protective effects of ascorbate and catalase on human spermatozoa during cryopreservation. J Androl. 2010, 31(5):437-444.
[23]. Wu X, Li Z, Wu C, et al. Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats. Endocr J. 2010, 57(3):201-209.